Systolic Hypertension in the Elderly Program (SHEP)

A randomized, multicenter clinical trial in 16 centers which tested the effectiveness of antihypertensive treatment in reducing the combined incidence of fatal and nonfatal stroke in 4,736 elderly patients with isolated systolic hypertension.

National Heart, Lung, and Blood Institute (NHLBI) and National Institute on Aging (NIA); 1984–1993 ($9,003,630).

Final Paper

SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991;265:3255-3264.

All Papers