Completed Projects
A randomized, multicenter clinical trial in three centers that determined the efficacy of reduced ambient-light exposure to reduce the incidence of retinopathy of prematurity in 409 premature infants.
Sponsored by the National Eye Institute (NEI); 1995-2000 ($441,535).
A randomized, double-blind, placebo-controlled, multicenter clinical trial in 30 centers that tested the effectiveness of intermittent transdermal nitroglycerin therapy on left ventricular dilatation and function in 300 post-myocardio infarction patients.
Sponsored by Schering-Plough, Inc.; 1992-1994 ($310,778).
A randomized, placebo-controlled, multicenter clinical trial in 80 centers that tested the effectiveness of pravastatin in reducing cardiovascular events in 4,159 post-mycardial infarction patients.
Sponsored by Bristol-Myers-Squibb, Inc.; 1989-2002 ($4,319,394).
A randomized, placebo-controlled, multicenter clinical trial in 40 centers that tested the effectiveness of captopril in reducing total mortality and/or ventricular enlargement in 2,231 post-myocardial infarction patients.
Sponsored by Bristol-Myers-Squibb, Inc.; 1986-1993 ($1,959,014).
A randomized multicenter study in 23 centers enrolling 4,099 infants in a natural history study with a randomized clinical trial that determined the safety and efficacy of cryotherapy of the retina in the treatment of retinopathy of prematurity in 291 premature infants.
Sponsored by the National Eye Institute (NEI); 1985-2003 ($4,534,242).
A randomized, multicenter clinical trial in 16 centers which tested the effectiveness of antihypertensive treatment in reducing the combined incidence of fatal and nonfatal stroke in 4,736 elderly patients with isolated systolic hypertension.
Sponsored by the National Heart, Lung, and Blood Institute (NHLBI)and National Institute on Aging (NIA); 1984-1993 ($9,003,630).
A three-center study of the effectiveness of dietary and pharmacological measures in treating 878 mild hypertensive patients.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1984-1993 ($1,058,316).
A randomized, double-blind, multicenter clinical trial designed to test the effectiveness of propranolol in reducing mortality in 3,837 post-myocardial infarction patients in 31 centers.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1984-1993 ($4,208,443).
A three-center study of the effectiveness of dietary measures in helping 479 previously treated HDFP participants remain off drug therapy.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1980-1984 ($421,871).
A three-center, cross-sectional study of the impact of information about high blood pressure on detection, awareness, and treatment of hypertension in three communities where HDFPclinical centers were located.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1977-1978 (funded in HDFP).
A longitudinal study of the three-year incidence of hypertension among 9,500 normotensive persons identified in 13 centers as part of the hypertension screening program of HDFP.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1973-1978 (funded in HDFP).
A clinical trial in 14 centers which investigated the differences in mortality and selected morbidity between 10,940 patients randomly allocated to either an intensive hypertension control program or referral back to the regular medical care system.
Sponsored by the National Heart, Lung and Blood Institute (NHLBI); 1971-1993 ($18,059,234).
