Cholesterol and Recurrent Events Trial (CARE)

A randomized, placebo-controlled, multicenter clinical trial in 80 centers that tested the effectiveness of pravastatin in reducing cardiovascular events in 4,159 post-mycardial infarction patients.

Sponsored by Bristol-Myers-Squibb, Inc.; 1989–2002 ($4,319,394).

Final Paper

Sacks FM, Pfeffer MA, Moyé LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JW, Arnold JM, Wun CC, Davis BR, Braunwald E. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996;335:1001-09.

Design Paper

Rationale and design of a secondary prevention trial of lowering normal plasma cholesterol levels after acute myocardial infarction: the Cholesterol and Recurrent Events trial [Published erratum appears in Am J Cardiol 1992;69:574]. Am J Cardiol 1991;68:1436-46.

All Papers